About MabThera in rheumatoid arthritis MabThera selectively targets a subset of B cells so that CD20, so that stem, pro – B and plasma cells unaffected. This subset of B-cells plays a major role in the autoimmune process of RA and MabThera aims this process through the inhibition of a series of reactions inflammation of the synovium, leading to cartilage and bone degradation erosion, which is characteristic of the disease interrupting. More than 1,000 RA patients have been treated with MabThera in clinical trials to date. An extensive phase III clinical development program is also currently to further investigate the potential clinical benefit of MabThera in earlier RA.
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